A friend who happens to be an academic psychiatrist reviewed The Science Chapter. He wrote, Pathophysiology of BP is really tough, even for us "bigwigs", and I hope you have some success summarizing it for a non-professional audience.
So I said, Hold my beer.
And here it is:
In a person with bipolar, a whole series of mis-timings and misalignments in our internal and external cycles results in a failure to rebalance. The list includes: dysregulation of hormones, neurotransmitters, and immune system; irregularities in communication between brain cells and within brain cells; and wonky wiring among the networks that connect the thinking, feeling, and evaluating parts of the brain.
Okay, that will take some unpacking, which I will do over the coming weeks. Meanwhile,
it's like this: